Related Experiment Video
Updated: Jun 23, 2026

Assay Development for High-Throughput Drug Screening Against Mycobacteria
Published on: October 25, 2024
Antimycobacterial activity of Exocarpos latifolius is due to exocarpic acid
Michael Koch1, Tim S Bugni, Chris D Pond
1Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA.
Abstract:
Lipophilic fractions of stem extracts from Exocarpos latifolius, native to Papua New Guinea, showed significant activity against Mycobacterium tuberculosis H37Ra. Bioactivity-guided fractionation yielded exocarpic acid (E-octadeca-13-ene-9,11-diynoic-acid) as the major active component. Several new exocarpic acid analogs were also shown to be active. Exocarpic acid has previously been reported active against gram-positive, but not gram-negative bacteria. Work presented here demonstrates the selective activity of exocarpic acid against Mycobacterium tuberculosis H37Ra.
Related Concept Videos
Antifungal Agents
Bacterial Phylum Actinobacteria
Antimicrobial Effectiveness
Antiprotozoal Agents
Surface Membrane Barriers
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
Tuberculosis
