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Osmolality-induced tuning of action potentials in trigeminal ganglion neurons

Lei Chen1, Changjin Liu, Lieju Liu

  • 1Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China. chenltj@hotmail.com

Neuroscience Letters
|May 16, 2009
PubMed

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The Role of Ion Channels in Neuronal Computation

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Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...