Related Experiment Video
Updated: Jun 23, 2026

The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats
Published on: March 8, 2019
Recurrent haemoptysis following sildenafil administration
Ramakant Dixit1, Pawan Jakhmola, Sidharth Sharma
1Department of Pulmonary Medicine and Tuberculosis, J.L.N. Medical College, Ajmer, India.
Sildenafil, used for erectile dysfunction, can cause mild side effects. This case study shows a potential link between sildenafil use and recurrent haemoptysis, a rare adverse event.
Area of Science:
- Pharmacology
- Urology
- Pulmonology
Background:
- Sildenafil is a common treatment for male erectile disorder.
- It is generally well-tolerated with known mild adverse effects like headache and dyspepsia.
Observation:
- A 38-year-old male experienced recurrent haemoptysis (coughing up blood).
- These episodes occurred shortly after self-administering sildenafil.
- No other causative factors for haemoptysis were identified.
Findings:
- The patient's recurrent haemoptysis episodes ceased upon discontinuing sildenafil.
- This suggests a potential causal relationship between sildenafil and haemoptysis.
Implications:
- Physicians should be aware of haemoptysis as a rare potential adverse effect of sildenafil.
- Further investigation may be warranted to understand this association.
Related Concept Videos
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Pneumothorax-II
Clinical Manifestations:
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
Pulmonary Hypertension: Classification and Pathogenesis
There are various classifications for PH, each relating to different underlying causes and also...
