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Diabetes: Management and Pharmacotherapy

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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...

Diabetes Mellitus: Overview and Type I Subtype

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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
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Improving IV Insulin Administration in a Community Hospital

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

Diabetes: glycaemic control in type 1.

Bala Srinivasan¹, Melanie Davies, Ian Lawrence

¹Department of Diabetes and Endocrinology, University Hospitals of Leicester NHS Trust, Leicester, UK.

BMJ Clinical Evidence

|May 19, 2009

Summary

This systematic review examines intensive treatment programs and educational interventions for type 1 diabetes. It evaluates different insulin regimens and blood glucose monitoring frequencies for improved glycemic control.

Area of Science:

Endocrinology
Metabolic Diseases
Autoimmune Disorders

Background:

Type 1 diabetes results from autoimmune destruction of pancreatic beta cells, leading to insulin deficiency.
Effective management is crucial for preventing long-term complications associated with hyperglycemia.

Purpose of the Study:

To systematically review the effectiveness and safety of intensive treatment programs and educational interventions for type 1 diabetes.
To evaluate the impact of different insulin regimens on glycemic control in adults and adolescents with type 1 diabetes.

Main Methods:

A systematic literature search was conducted across major databases (Medline, Embase, Cochrane Library) up to December 2006.
Included studies comprised systematic reviews, randomized controlled trials (RCTs), and observational studies.

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Last Updated: Jun 23, 2026

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Published on: June 11, 2012

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

GRADE methodology was used to assess the quality of evidence for interventions.

Main Results:

Sixteen systematic reviews, RCTs, or observational studies met the inclusion criteria.
Evidence quality was evaluated using the GRADE system.
Data on various interventions were synthesized.

Conclusions:

The review presents findings on the effectiveness and safety of different insulin administration frequencies (CSII vs. MDI).
Effectiveness of varying blood glucose self-monitoring frequencies was assessed.
Educational interventions and intensive treatment programs were evaluated for their impact on type 1 diabetes management.