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Metastasis

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Related Experiment Video

Updated: Jun 23, 2026

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

Published on: June 7, 2020

Brain metastases.

Susan Lalondrelle¹, Vincent Khoo

¹Royal Marsden NHS Foundation Trust, London, UK.

BMJ Clinical Evidence

|May 19, 2009

Summary

This summary is machine-generated.

This systematic review examines interventions for brain metastases, including surgery, radiation, and chemotherapy. It evaluates the effectiveness and safety of various treatments for managing these secondary brain tumors.

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Last Updated: Jun 23, 2026

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

Published on: June 7, 2020

Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis

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Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection

Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection

Published on: January 16, 2026

Area of Science:

Neuro-oncology
Clinical Neurology
Evidence-Based Medicine

Background:

Central nervous system metastases can originate from any primary tumor.
Brain metastases may be single or multiple, symptomatic or asymptomatic.
Effective management strategies are crucial for improving patient outcomes.

Purpose of the Study:

To systematically review the effects of interventions for managing brain metastases in adults.
To evaluate the effectiveness and safety of various treatment modalities.
To provide evidence-based information for clinical decision-making.

Main Methods:

Systematic review of 18 identified studies (systematic reviews, RCTs, observational studies).
Searched major databases (Medline, Embase, Cochrane Library) up to June 2007.
Included harms alerts from regulatory agencies (FDA, MHRA).

Main Results:

The review synthesized evidence on multiple interventions for brain metastases.
GRADE evaluation was performed to assess the quality of evidence for each intervention.
Information on effectiveness and safety was compiled for various treatment options.

Conclusions:

The review presents data on corticosteroids, chemotherapy, and radiotherapy-based interventions.
Surgical interventions, including combinations with radiotherapy and radiosurgery, were evaluated.
The findings provide a comprehensive overview of current management options for brain metastases.