Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Complications of Diabetes Mellitus01:22

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum to "Methods": Canadian Journal of Diabetes 2018;42(S1):S6-S9.

Canadian journal of diabetes·2018
Same author

Methods.

Canadian journal of diabetes·2018
Same author

Effect of computer-generated tailored feedback on glycemic control in people with diabetes in the community: a randomized controlled trial.

Diabetes care·2011
Same author

Diabetes: foot ulcers and amputations.

American family physician·2009
Same author

Annual incidence and relative risk of diabetes in people with various categories of dysglycemia: a systematic overview and meta-analysis of prospective studies.

Diabetes research and clinical practice·2007
Same author

Foot ulcers and amputations in diabetes.

Clinical evidence·2006

Related Experiment Video

Updated: Jun 23, 2026

Effects of Mindfulness Training Combined with Tai Chi in Patients with Diabetic Peripheral Neuropathy
05:06

Effects of Mindfulness Training Combined with Tai Chi in Patients with Diabetic Peripheral Neuropathy

Published on: July 14, 2023

Diabetes: foot ulcers and amputations.

Dereck Hunt1

  • 1McMaster University, Hamilton, Ontario, Canada.

BMJ Clinical Evidence
|May 19, 2009
PubMed
Summary
This summary is machine-generated.

This systematic review evaluates interventions for preventing and treating diabetic foot ulcers and amputations. It found evidence on various treatments, including debridement, skin substitutes, patient education, and off-loading devices.

Related Experiment Videos

Last Updated: Jun 23, 2026

Effects of Mindfulness Training Combined with Tai Chi in Patients with Diabetic Peripheral Neuropathy
05:06

Effects of Mindfulness Training Combined with Tai Chi in Patients with Diabetic Peripheral Neuropathy

Published on: July 14, 2023

Area of Science:

  • Podiatry
  • Diabetology
  • Wound Care

Background:

  • Diabetic foot ulceration is a serious complication of diabetes, characterized by full-thickness skin penetration.
  • The Wagner system classifies ulcer severity from grade 1 to 5.
  • High annual incidence rates for diabetic foot ulcers and amputations are reported globally.

Purpose of the Study:

  • To systematically review the effects of interventions for preventing foot ulcers and amputations in individuals with diabetes.
  • To evaluate the effectiveness of treatments for existing diabetic foot ulcerations.

Main Methods:

  • A systematic review was conducted, searching major databases up to November 2007.
  • Included studies comprised 41 systematic reviews and randomized controlled trials (RCTs).
  • Harms alerts from regulatory agencies were also incorporated.

Main Results:

  • The review identified numerous interventions for diabetic foot complications.
  • A GRADE evaluation assessed the quality of evidence for various interventions.
  • Specific interventions reviewed include debridement, skin substitutes, patient education, off-loading devices, and hyperbaric oxygen therapy.

Conclusions:

  • The review synthesizes evidence on the effectiveness and safety of diverse interventions for diabetic foot ulcers.
  • Key interventions discussed include debridement, skin equivalents, patient education, pressure off-loading, and wound dressings.
  • Findings inform clinical practice regarding the management of diabetic foot complications.