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BMJ clinical evidence·2015

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BMJ clinical evidence·2011

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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

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Published on: June 2, 2014

Migraine headache in children.

Nick Peter Barnes¹, Elizabeth Katherine James

¹Northampton General Hospital, Northampton, UK.

BMJ Clinical Evidence

|May 19, 2009

Summary

This summary is machine-generated.

This systematic review evaluates treatments for pediatric migraine, covering acute symptom relief and prophylaxis. It found various interventions effective for managing childhood migraine attacks and preventing recurrence.

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Area of Science:

Pediatric Neurology
Clinical Pharmacology

Background:

Childhood migraine diagnosis is challenging due to subjective symptoms and broader criteria than in adults.
Migraine prevalence in children is 3-10%, increasing with age, with potential for persistence into adulthood if starting in adolescence.

Purpose of the Study:

To systematically review the effectiveness and safety of treatments for acute migraine attacks in children.
To evaluate prophylactic treatments for migraine headache in children.

Main Methods:

Systematic review of 18 studies including systematic reviews, RCTs, and observational studies.
Searched major databases (Medline, Embase, Cochrane Library) up to May 2008.
Included harms alerts from regulatory agencies like the FDA and MHRA.

Main Results:

Identified interventions for acute symptom relief including antiemetics, NSAIDs, paracetamol, and 5HT1 antagonists (triptans).
Identified prophylactic interventions such as beta-blockers, dietary manipulation, pizotifen, and behavioral therapies (stress management, biofeedback).
Evaluated the quality of evidence for various interventions using the GRADE system.

Conclusions:

Information on the effectiveness and safety of multiple acute and prophylactic migraine treatments for children is presented.
The review covers a range of pharmacological and non-pharmacological interventions for pediatric migraine management.
This systematic review provides a comprehensive overview of current treatment options for childhood migraine.