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Updated: Jun 23, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
Published on: September 16, 2011
Diagnosing immune-mediated reactions to drugs
A T Nagao-Dias1, F M Teixeira, H L L Coelho
1Dept. Clinical Analysis and Toxicology, Faculty of Pharmacy, Universidade Federal do Ceará, Brazil. tiemindi@yahoo.com.br
Abstract:
Drug allergy is a type B adverse drug reaction, which is unpredictable and difficult to prevent or manage. In patients who have a previous history of drug allergy it must be confirmed by laboratorial diagnosis. However, the diagnostic test remains a major problem in clinical practice. Skin testing is validated for some drugs, such as penicillin, but not for others. Provocation test is a confirmatory test but bears the risk of severe reactions. Lymphocyte transformation test is a reliable test but is considered as a research tool. This review addresses the most recent published literature regarding the techniques which have already been developed as well as the new tests that can be promising alternatives for diagnosis of drug allergy.
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