Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Suppression of thyroid function by interferon-alpha 2 in man.

C J Wiedermann1, W Vogel, H Tilg

  • 1Department of Internal Medicine, University of Innsbruck, Austria.

Naunyn-Schmiedeberg'S Archives of Pharmacology
|June 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Teachers' emotional well-being during the SARS-CoV-2 pandemic with long school closures: a large-scale cross-sectional survey in Northern Italy.

Public health·2022
Same author

[Albumin in traumatic brain injury-many unanswered questions!]

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2022
Same author

Acute kidney injury in critically burned patients treated with hydroxyethyl starch: a response to Sánchez-Sánchez et al.

Annals of burns and fire disasters·2018
Same author

Weekend effects on health outcomes and operational efficiency in emergency admissions to general medicine services of the Central Hospital of the Autonomous Province of Bolzano, Italy.

Annali di igiene : medicina preventiva e di comunita·2018
Same author

Antithrombin concentrate use in disseminated intravascular coagulation of sepsis: meta-analyses revisited.

Journal of thrombosis and haemostasis : JTH·2018
Same author

Impairment of innate immune function by hydroxyethyl starch.

British journal of anaesthesia·2016

Subcutaneous alpha-interferon (IFN) treatment can impact thyroid function. Even low doses of IFN significantly decrease thyroid stimulating hormone and reduce thyroxine and triiodothyronine levels.

Area of Science:

  • Endocrinology
  • Immunology
  • Pharmacology

Background:

  • Interferon therapy is known to induce significant biological changes.
  • Observed endocrine alterations prompted an investigation into interferon's effects on the thyroid axis.

Purpose of the Study:

  • To investigate the effects of single-dose subcutaneous recombinant alpha-interferon (IFN) on thyroid hormone levels.
  • To assess changes in thyroid stimulating hormone (TSH), total thyroxine (T4), and total triiodothyronine (T3) following IFN administration.

Main Methods:

  • 10 volunteers (5 healthy, 5 with hepatitis C) received single subcutaneous doses of IFN (1, 3, or 5 x 10^6 units).
  • Blood samples were collected pre-injection and at 2, 12, 24, 48, and 72 hours post-injection.
  • Plasma hormone levels were measured using commercial test kits.

Related Experiment Videos

Main Results:

  • A dose of 5 x 10^6 units of IFN significantly increased cortisol levels.
  • This dose also significantly decreased TSH levels starting at 12 hours post-injection.
  • Maximum TSH suppression and significant reductions in T4 and T3 levels were observed 24 hours post-injection.

Conclusions:

  • Subcutaneous alpha-interferon administration, even at doses as low as 5 x 10^6 units, affects thyroid function control.
  • IFN treatment can lead to significant alterations in thyroid hormone levels, indicating a need for monitoring during therapy.