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Updated: Jun 23, 2026
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Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
[Low birth weight is a risk factor for type 1 diabetes].
B García Cuartero1, A González Vergaz, S Herranz
1Unidad de Endocrinología Pediátrica, Servicio de Pediatría Hospital Universitario Severo Ochoa, Leganés Madrid, Spain. bgarciac.hsvo@salud.madrid.org
Anales De Pediatria (Barcelona, Spain : 2003)
|May 19, 2009
Summary
Children with type 1 diabetes mellitus (T1DM) often have lower birth weight and a significant increase in body mass index (BMI) during early life. These factors may indicate intrauterine influences as a risk for T1DM.
Area of Science:
- Pediatrics
- Endocrinology
- Metabolic Disorders
Context:
- Type 1 diabetes mellitus (T1DM) incidence is rising, particularly in children.
- Childhood obesity is increasingly linked to T1DM development.
- Understanding early life factors influencing T1DM onset is crucial.
Purpose:
- To investigate the relationship between birth weight, early-life BMI changes, and BMI at diagnosis with age at T1DM diagnosis in children.
- To explore potential links between intrauterine factors and T1DM risk.
Summary:
- This study analyzed 100 Caucasian children with T1DM.
- Results showed lower birth weight and BMI at birth in T1DM patients compared to controls.
- A significant BMI increase in the first two years of life was observed in T1DM children, with lower birth BMI correlating with younger age at diagnosis.
Impact:
- Identifies low birth weight and rapid early-life BMI gain as potential risk factors for T1DM.
- Suggests the intrauterine environment may play a role in T1DM etiology.
- Provides insights for early identification and potential intervention strategies for T1DM.
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