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Cost-effectiveness of infant vaccination with RIX4414 (Rotarix) in the UK

A Martin1, A Batty, J A Roberts

  • 1GlaxoSmithKline Ltd., Stockley Park, Middlesex, UK.

Vaccine
|May 19, 2009
PubMed

Insights

Infant rotavirus vaccination with Rotarix is cost-effective in the UK, considering all infections. This vaccination strategy offers value for money from both societal and National Health Service (NHS) perspectives.

Area of Science:

  • Public Health
  • Health Economics
  • Vaccinology

Background:

  • Rotavirus infection poses a significant burden on healthcare systems and society.
  • Estimating the full economic impact requires considering infections outside of formal healthcare encounters.
  • Rotavirus vaccination is a key public health intervention.

Purpose of the Study:

  • To evaluate the cost-effectiveness of Rotarix infant rotavirus vaccination in the UK.
  • To incorporate community-acquired rotavirus infections into the economic model.
  • To assess vaccination from both National Health Service (NHS) and societal perspectives.

Main Methods:

  • A lifetime Markov model was developed for a hypothetical UK birth cohort.
  • Costs and Quality-Adjusted Life-Years (QALYs) were estimated for vaccinated and unvaccinated scenarios.
  • Societal costs included work absence and parental travel; NHS costs included healthcare utilisation.

Main Results:

  • The base case cost-effectiveness ratios were £23,298/QALY (NHS perspective) and £11,459/QALY (societal perspective).
  • Sensitivity analyses identified hospitalisation costs and GP consultation numbers as key drivers.
  • Rotavirus vaccination is projected to be cost-effective within NICE thresholds.

Conclusions:

  • Rotavirus vaccination with Rotarix is a cost-effective policy for the UK.
  • The inclusion of community rotavirus infections strengthens the economic case for vaccination.
  • This supports the integration of Rotarix into the routine paediatric vaccination schedule.

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