Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...
Precipitate Formation and Particle Size Control01:16

Precipitate Formation and Particle Size Control

In precipitation gravimetry, the precipitating agent should react specifically or selectively with the analyte. While a specific reagent reacts with the analyte alone, a selective reagent can react with a limited number of chemical species.
The obtained precipitate should be either a pure substance of known composition or easily converted to one by a simple process, such as ignition or drying. In addition, the precipitate should be insoluble and easily filterable. In general, filterability...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Computerized tomography angiography in diagnosing an obtuse marginal branch perforation after pericardiocentesis: a case report.

Frontiers in cardiovascular medicine·2025
Same author

Bone mineral density as potential individual prognostic biomarker in patients with neurosurgically treated spinal metastasis.

Journal of cancer research and clinical oncology·2025
Same author

The burden of type 2 diabetes mellitus in Latin America, 1990-2019: findings from the Global Burden of Disease study.

Public health·2024
Same author

Prognosis of patients with previous myocardial infarction, coronary slow flow, and normal coronary angiogram.

Herz·2019
Same author

[ASSOCIATION OF SKIN PHOTOTYPE AND UV EXPOSURE WITH EXPRESSION OF HER RECEPTORS, Ki67 AND p53 IN PATIENTS WITH CUTANEOUS SQUAMOUS CELL CARCINOMA].

Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti·2017
Same author

Ischemic preconditioning vs adenosine vs prostaglandin E1 for protection against liver ischemia/reperfusion injury.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2017

Related Experiment Video

Updated: Jun 23, 2026

Characteristics of Precipitation-formed Polyethylene Glycol Microgels Are Controlled by Molecular Weight of Reactants
11:32

Characteristics of Precipitation-formed Polyethylene Glycol Microgels Are Controlled by Molecular Weight of Reactants

Published on: December 23, 2013

Microparticle size control and glimepiride microencapsulation using spray congealing technology.

I Ilić1, R Dreu, M Burjak

  • 1University of Ljubljana, Faculty of Pharmacy, Askerceva 7, SI-1000 Ljubljana, Slovenia.

International Journal of Pharmaceutics
|May 19, 2009
PubMed
Summary

Spray congealing efficiently produces drug-free and glimepiride microparticles. Gelucire 50/13 significantly enhances glimepiride dissolution, though storage can cause morphological changes.

More Related Videos

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

Preparation of Cross-Linked Sodium Alginate Microspheres with Different Metal Ions Using the Microfluidic Electrospray Technology
07:24

Preparation of Cross-Linked Sodium Alginate Microspheres with Different Metal Ions Using the Microfluidic Electrospray Technology

Published on: June 7, 2024

Related Experiment Videos

Last Updated: Jun 23, 2026

Characteristics of Precipitation-formed Polyethylene Glycol Microgels Are Controlled by Molecular Weight of Reactants
11:32

Characteristics of Precipitation-formed Polyethylene Glycol Microgels Are Controlled by Molecular Weight of Reactants

Published on: December 23, 2013

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

Preparation of Cross-Linked Sodium Alginate Microspheres with Different Metal Ions Using the Microfluidic Electrospray Technology
07:24

Preparation of Cross-Linked Sodium Alginate Microspheres with Different Metal Ions Using the Microfluidic Electrospray Technology

Published on: June 7, 2024

Area of Science:

  • Pharmaceutical Technology
  • Materials Science

Background:

  • Microparticle formulation is crucial for drug delivery.
  • Optimizing spray congealing parameters impacts particle characteristics.
  • Enhancing solubility of poorly water-soluble drugs like glimepiride is a key challenge.

Purpose of the Study:

  • To investigate the influence of spray congealing parameters on microparticle size and yield.
  • To prepare and characterize glimepiride-loaded microparticles using hydrophilic carriers.
  • To evaluate the dissolution enhancement and storage stability of glimepiride microparticles.

Main Methods:

  • Spray congealing process with controlled atomizing pressure and liquid feed rate.
  • Preparation of glimepiride microparticles using Gelucire 50/13, poloxamer 188, and PEG 6000.
  • Characterization using particle size analysis, X-ray powder diffraction (XRPD), and dissolution testing.
  • Storage stability study under controlled temperature and humidity.

Main Results:

  • Microparticle size ranged from 58 to 278 microm, with yields of 81-96%.
  • Atomizing pressure was the dominant parameter influencing microparticle size.
  • Glimepiride microparticles showed no change in crystallinity; Gelucire 50/13 provided the best dissolution enhancement.
  • Storage induced a
  • blooming
  • effect with leaf-like structure formation in glimepiride/Gelucire 50/13 microparticles.

Conclusions:

  • Spray congealing is a viable method for producing microparticles with controllable sizes.
  • Gelucire 50/13 is a promising carrier for enhancing glimepiride solubility and dissolution rate.
  • Storage stability requires further investigation due to observed morphological changes.