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Updated: Jun 23, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
A new biodegradable crosslinked polyethylene oxide sulfide (PEOS) hydrogel for controlled drug release
Heebeom Koo1, Geun-Woo Jin, Hyunseo Kang
1School of Chemistry & Molecular Engineering, Seoul National University, Shillim-dong, Kwanak-ku, Seoul, Republic of Korea.
Abstract:
We developed a polyethylene glycol (PEG)-based biodegradable hydrogel through disulfide crosslinking of polyethylene oxide sulfide (PEOS). The crosslinking rate was highly dependent on temperature, and incubation at about 40-50 degrees C was required for efficient crosslinking. The crosslinked PEOS hydrogel showed glutathione-dependent dissolution and corresponding controlled release of a model drug-fluorescein isothiocyanate (FITC)-labeled dextran-because the disulfide bond, the main linker, is selectively degraded in response to the high concentration of glutathione. The temperature-sensitive crosslinking and the hydrogel formation have the potential for use as an injectable biogel precursor, which was confirmed by in situ gel formation in mice.
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