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CD83 polymorphisms and cervical cancer risk.

Kelly J Yu1, Janet S Rader, Ingrid Borecki

  • 1Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20852, USA. yuke@mail.nih.gov

Gynecologic Oncology
|May 19, 2009
PubMed
Summary
This summary is machine-generated.

Genetic variations in the CD83 gene are linked to reduced cervical cancer risk. These CD83 gene polymorphisms may also influence cancer type, particularly adenocarcinoma.

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Area of Science:

  • Genetics and Immunology
  • Oncology
  • Cancer Epidemiology

Background:

  • Polymorphisms in immune recognition genes are associated with cervical cancer risk.
  • Previous studies suggest a link between CD83 single nucleotide polymorphisms (SNPs) and cervical cancer.
  • The influence of these SNPs on disease characteristics requires further investigation.

Purpose of the Study:

  • To replicate findings on CD83 SNPs and cervical cancer risk.
  • To examine if CD83 SNP effects vary by age, clinical stage, and tumor histology.
  • To explore the association between CD83 gene variations and cervical cancer susceptibility.

Main Methods:

  • A multicenter case-control study in the Eastern United States (263 cases, 307 controls).
  • Evaluation of five specific CD83 SNPs previously associated with cervical cancer.
  • Pooled analysis combining data from the current study and a prior report (total 640 cases) to assess effects on age, stage, and histology.

Main Results:

  • One CD83 SNP (rs750749) showed a significant reduction in cervical cancer risk for CT/CC genotype carriers (p-trend=0.02).
  • Two additional SNPs (rs9296925, rs9370729) showed non-significant trends towards reduced risk.
  • Pooled analysis indicated that adenocarcinoma cases were more likely to carry susceptibility alleles for SNPs rs9370729 and rs750749 (p-trend=0.02 and p-trend=0.09, respectively).

Conclusions:

  • This study confirms an association between CD83 gene polymorphisms and cervical cancer risk.
  • The findings suggest that the relationship between CD83 variations and cervical cancer may differ based on tumor histology, particularly in adenocarcinomas.