Anaphylactic shock during the sentinel lymph node procedure for cervical cancer

Area of Science:

• Oncology
• Surgical Pathology
• Anesthesiology

Background:

• Patent blue dye is frequently used for sentinel node (SN) detection in solid tumors.
• Allergic reactions to patent blue, though uncommon, can occur during surgical procedures.
• Anaphylaxis to patent blue is particularly rare in the context of cervical cancer surgery.

Observation:

• A rare case of anaphylactic shock occurred in a cervical cancer patient following patent blue injection for SN mapping.
• The study details the management of the anaphylactic reaction and the diagnostic process for identifying the allergen.
• Treatment of the underlying cervical cancer proceeded after the patient's anaphylactic episode was managed.

Findings:

• Sentinel node mapping with patent blue can precipitate rare anaphylactic reactions.
• Early recognition and management of anaphylaxis are critical in surgical oncology.
• Diagnostic workup is essential to confirm patent blue as the causative agent.

Implications:

• Healthcare providers must maintain vigilance for potential patent blue hypersensitivity during SN procedures.
• Awareness of this rare complication is vital for surgeons and anesthesiologists.
• This case highlights the importance of preparedness for adverse drug reactions in oncologic surgery.