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Related Experiment Video

Updated: Jun 23, 2026

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

Levetiracetam-induced platelet dysfunction.

Marie Hacquard1, Sébastien Richard, Jean-Christophe Lacour

  • 1Hématologie Biologique, CHU Nancy, allée du Morvan, Vandoeuvre-les-Nancy, France. m.toussaint-hacquard@chu-nancy.fr

Epilepsy Research
|May 19, 2009
PubMed
Summary
This summary is machine-generated.

Levetiracetam, an antiepileptic drug, may alter platelet function. Platelet function improved after discontinuing levetiracetam, suggesting a link between this drug and bleeding risks.

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Area of Science:

  • Pharmacology
  • Hematology
  • Neurology

Background:

  • Levetiracetam is a widely prescribed antiepileptic medication.
  • Platelet function is crucial for hemostasis.
  • Previous literature has not reported levetiracetam's effect on platelets.

Observation:

  • A potential alteration in platelet function was observed in patients taking levetiracetam.
  • This effect is novel and has not been previously documented in medical literature.
  • The observed platelet dysfunction was reversible upon cessation of levetiracetam therapy.

Findings:

  • Levetiracetam administration was associated with impaired platelet function.
  • Restoration of normal platelet functionality occurred after the drug was stopped.
  • A structurally similar compound, piracetam, has been associated with similar effects.

Implications:

  • This finding suggests a potential risk of bleeding complications associated with levetiracetam use.
  • Clinicians should be aware of this potential side effect when prescribing levetiracetam.
  • Further research is warranted to elucidate the precise mechanism of levetiracetam-induced platelet dysfunction.