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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

The Retinoblastoma Gene

The Retinoblastoma Gene

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...

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Related Experiment Video

Updated: Jun 23, 2026

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

Rhabdomyosarcoma in children.

Andrea Hayes-Jordan¹, Richard Andrassy

¹University of Texas MD Anderson Cancer Center, University of Texas Houston Health Sciences Center, Houston, TX 77030, USA. ahjordan@mdanderson.org

Current Opinion in Pediatrics

|May 19, 2009

Summary

This review details the diagnosis, assessment, and treatment of rhabdomyosarcoma, a rare childhood cancer. It highlights a new risk classification system improving survival rates for affected children.

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

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Last Updated: Jun 23, 2026

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Area of Science:

Pediatric Oncology
Cancer Research
Rare Diseases

Background:

Rhabdomyosarcoma is a rare pediatric malignancy affecting approximately 300 children annually in the US.
Accurate diagnosis and timely treatment are crucial for improving patient outcomes.

Purpose of the Study:

To enhance understanding of the complex diagnosis, assessment, and treatment of pediatric rhabdomyosarcoma.
To serve as a reference for practitioners encountering suspected cases in children.

Main Methods:

Review of current literature and clinical protocols.
Focus on the Children's Oncology Group's new risk classification system.
Compilation of essential diagnostic tests and imaging modalities.

Main Results:

Introduction of a new risk classification (low, intermediate, high) replacing previous staging and grouping.
Identification of diagnostic criteria and imaging requirements for rhabdomyosarcoma.
Demonstration of significant survival improvements over the past 25 years.

Conclusions:

The new risk classification is foundational for current rhabdomyosarcoma treatment protocols.
Rapid diagnosis and appropriate management are key to improving long-term survival.
Overall survival for rhabdomyosarcoma has reached 70%, with some sites achieving up to 90% survival.