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Updated: Jun 23, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
[Th17 cells - a new proinflammatory T cell population and its role in rheumatologic autoimmune diseases]
J Leipe1, A Skapenko, H Schulze-Koops
1Rheumaeinheit, Medizinische Poliklinik, Klinikum der Universität München, München. jan.leipe@med.uni-muenchen.de
Abstract:
CD4 T cells play a major role in the development and persistence of autoimmune rheumatic diseases. The recent identification of IL-17-producing Th17 cells as a potent proinflammatory subset extends the understanding of pathophysiological processes not explained by the Th1/Th2 dichotomy. The recent data from human studies discussed in this article indicate an important pathogenic function for Th17 cells and Th17-derived IL-17 suggesting that therapies targeting Th17 cells/IL-17 may be of potential use in the treatment of those diseases.
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