Related Experiment Video
Updated: Jun 23, 2026

Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice
Published on: March 15, 2024
Childhood depressive symptoms and adolescent cigarette use: a six-year longitudinal study controlling for peer
Mitchell J Prinstein1, Annette M La Greca
1Department of Psychology, University of North Carolina, Chapel Hill, NC, USA. mitch.prinstein@unc.edu
Objective:
To examine potential pathways between childhood depressive symptoms and adolescent cigarette use, controlling for potential "third variable" causes.
Design:
Participants included 250 youth (60% girls) who were in Grades 4 to 6 at study outset and in Grades 10 to 12 (M age = 16.78) at a 6-year follow-up. At Time 1, children completed measures of depressive symptoms, as well as peer nominations of peer acceptance, rejection, and aggressive behavior.
Main Outcome Measures:
Time 2 measures included adolescents' own and close friends' cigarette use, depressive symptoms, and externalizing behaviors; parents also reported on adolescent behaviors.
Results:
Higher levels of childhood depressive symptoms and aggressive behavior were associated longitudinally with cigarette use in adolescence. After controlling for other associations, higher levels of childhood depressive symptoms also were associated with higher levels of friends' cigarette use in adolescence and higher levels of adolescent depressive symptoms; each of these adolescent outcomes was concurrently associated with cigarette use.
Conclusion:
Depressive symptoms in childhood may lead to altered developmental trajectories that either directly or indirectly contribute to adolescent outcomes, including cigarette use.
Related Concept Videos
Influence of Parents and Peers on Identity
Parental Influence on Identity Development
Parents serve as primary guides and managers in an adolescent's life, offering support instrumental in decision-making and personal growth. This guiding role...
Cognitive Development During Adolescence
Stress Prevention and Stress Management Techniques IV
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Stress and Mental Health
Individuals with depression often experience challenges in both their personal and professional...
Sources of Self-Esteem I: Family Experience

