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Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Uterus and Cervix01:18

Uterus and Cervix

The uterus, commonly called the womb, is a vital reproductive organ in females designed to provide a nurturing environment for the implantation and growth of an embryo. It is shaped like a hollow pear and positioned between the urinary bladder and the rectum. The uterus's structure allows it to support and protect a developing fetus throughout pregnancy.
The uterus is securely anchored within the pelvic cavity by paired broad ligaments on either side. It is further stabilized by three pairs of...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

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Related Experiment Video

Updated: Jun 23, 2026

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
06:57

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

Cervical cancer.

Sudha Sundar1, Amanda Horne, Sean Kehoe

  • 1Pan Birmingham Gynaecological Cancer Centre, City Hospital and Division of Cancer Studies, University of Birmingham, Birmingham, United Kingdom.

BMJ Clinical Evidence
|May 20, 2009
PubMed
Summary

This systematic review evaluates interventions for early-stage cervical cancer. It covers HPV vaccination, conisation, chemotherapy, radiotherapy, and surgery, assessing their effectiveness and safety.

Area of Science:

  • Oncology
  • Gynecologic Oncology
  • Public Health

Background:

  • Cervical cancer is the second most common cancer globally in women, with peak prevalence in women aged 20-30.
  • While most infections resolve spontaneously, cervical cancer incidence in the UK has decreased due to screening programs.
  • Survival rates vary significantly by stage, from nearly 100% for stage Ia to 5-15% for stage IV.

Purpose of the Study:

  • To systematically review interventions for managing early-stage cervical cancer.
  • To assess the effects of interventions for bulky early-stage cervical cancer.
  • To evaluate the effectiveness and safety of various treatment modalities.

Main Methods:

  • A systematic review of medical literature was conducted, searching databases like Medline, Embase, and The Cochrane Library up to November 2006.

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Generation and Genetic Manipulation of Human Cervical Organoids
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Generation and Genetic Manipulation of Human Cervical Organoids

Published on: March 10, 2026

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Last Updated: Jun 23, 2026

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
06:57

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

Generation and Genetic Manipulation of Human Cervical Organoids
10:29

Generation and Genetic Manipulation of Human Cervical Organoids

Published on: March 10, 2026

  • Included studies were systematic reviews, randomized controlled trials (RCTs), and observational studies.
  • GRADE evaluation was used to assess the quality of evidence for interventions, including harms alerts from regulatory agencies.

    • Main Results:

    • Eighteen systematic reviews, RCTs, or observational studies met the inclusion criteria.
    • The review synthesized evidence on the effectiveness and safety of various interventions.
    • GRADE methodology was applied to evaluate the quality of evidence.

    Conclusions:

    • The review presents information on the effectiveness and safety of interventions for early and bulky early-stage cervical cancer.
    • Interventions discussed include HPV vaccine, conisation, neoadjuvant chemotherapy, radiotherapy, chemoradiotherapy, and surgery.
    • Evidence supports various treatment options depending on the stage and characteristics of the cervical cancer.