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Related Experiment Video

Updated: Jun 23, 2026

A Murine Model of Group B Streptococcus Vaginal Colonization

A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

Neonatal infections: group B streptococcus.

¹Department of Pediatrics, University of South Alabama, Mobile, AL, USA.

BMJ Clinical Evidence

|May 20, 2009

Summary

This summary is machine-generated.

Prophylactic antibiotic treatment for asymptomatic neonates with group B streptococcus (GBS) risk factors is reviewed. Evidence on antibiotics, monitoring, and selective treatment effectiveness and safety is presented.

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A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

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Last Updated: Jun 23, 2026

A Murine Model of Group B Streptococcus Vaginal Colonization

A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Area of Science:

Neonatal Medicine
Infectious Diseases
Pharmacology

Background:

Group B Streptococcus (GBS) is a common vaginal bacterium.
GBS can cause severe neonatal infections like sepsis, pneumonia, and meningitis, especially in premature infants.
Late-onset GBS infections present later but can still be serious.

Purpose of the Study:

To systematically review the effects of prophylactic treatment in asymptomatic neonates under 7 days old with GBS risk factors.
To evaluate the effectiveness and safety of various interventions for preventing GBS infection.

Main Methods:

Systematic review of literature including Medline, Embase, and The Cochrane Library up to March 2007.
Inclusion of twelve systematic reviews, RCTs, and observational studies.
GRADE evaluation of evidence quality for interventions.

Main Results:

Twelve studies met the inclusion criteria for the systematic review.
GRADE methodology was used to assess the quality of evidence for different interventions.
Information on the effectiveness and safety of various prophylactic strategies was gathered.

Conclusions:

The review presents data on the effectiveness and safety of different antibiotic regimens.
Monitoring and selective treatment strategies were evaluated.
Routine antibiotic prophylaxis for GBS in at-risk neonates was assessed.