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Related Experiment Video

Updated: Jun 23, 2026

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

Paracetamol (acetaminophen) poisoning.

Nick Buckley¹, Michael Eddleston

¹Canberra Hospital, Canberra, Australia.

BMJ Clinical Evidence

|May 20, 2009

Summary

This summary is machine-generated.

Paracetamol overdose can cause severe liver damage, but treatments exist. This review evaluates interventions for acute paracetamol poisoning, assessing their effectiveness and safety.

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Last Updated: Jun 23, 2026

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl₄) Exposure Through an Orogastric Tube

Published on: April 28, 2020

Area of Science:

Toxicology
Pharmacology
Evidence-Based Medicine

Background:

Paracetamol overdose is a significant cause of liver damage, with severe hepatotoxicity occurring in at least half of untreated individuals exceeding UK treatment levels.
While mortality is low (0.4%), prompt treatment is crucial to prevent liver injury.

Purpose of the Study:

To systematically review the effects of various treatments for acute paracetamol poisoning.
To evaluate the effectiveness and safety of interventions for paracetamol overdose.

Main Methods:

Systematic review of 24 studies, including systematic reviews, RCTs, and observational studies.
Searched major databases (Medline, Embase, Cochrane Library) up to March 2006.
Included harms alerts from regulatory agencies (FDA, MHRA) and performed GRADE evaluation.

Main Results:

Evaluated interventions include activated charcoal, gastric lavage, ipecacuanha, liver transplant, methionine, and N-acetylcysteine.
Evidence quality for interventions was assessed using the GRADE system.

Conclusions:

This systematic review synthesizes evidence on interventions for acute paracetamol poisoning.
Information on the effectiveness and safety of key treatments is presented.