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Updated: Jun 23, 2026

In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
Published on: May 12, 2023
Synthesis, spectroscopic characterization, X-ray structure and evaluation of binding parameters of new
Zia-ur Rehman1, Afzal Shah, Niaz Muhammad
1Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Abstract:
Three new triorganotin(IV) dithiocarboxylates (1-3) with general formula R(3)SnL, where R=C(4)H(9) (1), C(6)H(11) (2), C(6)H(5) (3) and L=4-(4-nitrophenyl)piperazine-1-carbodithioate, have been synthesized and characterized by elemental analysis, Raman, FT-IR, multinuclear NMR ((1)H, (13)C and (119)Sn) and mass spectrometry. The crystal structure of complex 3 confirmed distorted trigonal-bipyramidal geometry around Sn atom. The interaction of compounds 1-3 with DNA was investigated by cyclic voltammetry (CV) and UV-vis spectroscopy. The positive peak potential shift in CV and hypochromic effect in spectroscopy evidenced intercalative mode of interaction. The results indicate that the binding affinity varies in this sequence: 1>3>2.
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