Related Experiment Video
Updated: Jun 23, 2026

mirMachine: A One-Stop Shop for Plant miRNA Annotation
Published on: May 1, 2021
Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells
Marina Chekulaeva1, Witold Filipowicz
1Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland. chekulae@fmi.ch
Abstract:
MicroRNAs (miRNAs) are 20-nt-long to 24-nt-long noncoding RNAs acting as post-transcriptional regulators of gene expression in animals and plants. In mammals, more than 50% of mRNAs are predicted to be the subject of miRNA-mediated control but mechanistic aspects of the regulation are not fully understood and different studies have produced often-contradictory results. miRNAs can affect both the translation and stability of mRNAs. In this report, we review current progress in understanding how miRNAs execute these effects in animals and we discuss some of the controversies regarding different modes of miRNA function.
Related Concept Videos
MicroRNAs
MicroRNAs
MicroRNAs
Regulation of Expression at Multiple Steps
Experimental RNAi
Regulation of Expression Occurs at Multiple Steps
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...

