Related Experiment Video
Updated: Jun 23, 2026

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
Published on: August 29, 2025
Anxiety in children with CFS/ME
Esther Crawley1, Linda Hunt, Paul Stallard
1Centre of Child and Adolescent Health, Hampton House, Cotham Hill, Bristol BS6 6JS, UK. esther.crawley@bristol.ac.uk
Anxiety symptoms are prevalent in children with Chronic Fatigue Syndrome or Myalgic Encephalomyelitis (CFS/ME), especially in teenage girls. However, these anxiety symptoms do not appear linked to school attendance or disability measures.
Area of Science:
- Pediatric Health
- Psychology
- Chronic Illness Management
Background:
- Anxiety symptoms are frequently reported in pediatric Chronic Fatigue Syndrome or Myalgic Encephalomyelitis (CFS/ME).
- Limited data exists on the specific types of anxiety and their correlation with school attendance, disability, or fatigue in this population.
Purpose of the Study:
- To determine the prevalence and types of anxiety symptoms in children with CFS/ME compared to a general European population.
- To examine the association between anxiety symptoms and factors like age, gender, school attendance, fatigue, and physical function in pediatric CFS/ME.
Main Methods:
- Prospective data collection from children and adolescents referred to a specialist CFS/ME service.
- Utilized the Spence Children's Anxiety Scale for 164 pediatric CFS/ME patients with complete data.
Main Results:
- Teenage girls exhibited the highest rates of anxiety symptoms (38%), significantly exceeding the general population's top 10%.
- Separation anxiety and social phobia were notably elevated in younger girls with CFS/ME.
- No significant association was found between anxiety symptoms and school attendance, time to assessment, pain, or age.
Conclusions:
- Anxiety symptoms are common in pediatric CFS/ME, particularly among teenage girls, but are not demonstrably linked to school attendance or disability.
- Separation anxiety and social phobia are the most prominent anxiety types observed in children diagnosed with CFS/ME.
Related Concept Videos
Cystic Fibrosis: Management
Sinus disease and chronic sinusitis...
Social Anxiety Disorder
Anxiety: Overview
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Generalized Anxiety Disorder
Autism Spectrum Disorder
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.