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Flow Cytometry01:23

Flow Cytometry

The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
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Quality counts: new parameters in blood cell counting.

C Briggs1

  • 1Department of Haematology, University College London Hospital, London, UK. carolbriggs@hotmail.com

International Journal of Laboratory Hematology
|May 20, 2009
PubMed
Summary

New complete blood count parameters offer diagnostic potential but lack quality control. Establishing external quality assessment schemes is crucial for their clinical adoption and reliable use in hematology.

Area of Science:

  • Hematology
  • Clinical Pathology
  • Laboratory Medicine

Background:

  • The complete blood count (CBC) has expanded with new parameters like nucleated red blood cells, immature granulocytes, and immature platelet fraction.
  • Leukocyte positional parameters show promise for diagnosing diseases, including differentiating leukemia from viral conditions and detecting malaria.
  • Emerging CBC parameters are currently for research but may become reportable, necessitating quality assessment.

Purpose of the Study:

  • To discuss the importance and potential inclusion of new and established hematology parameters in external quality assessment schemes (EQAS).
  • To gather consensus on which parameters are most critical for future EQAS development.

Main Methods:

  • Review of recently introduced CBC parameters and their potential clinical applications.

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  • Discussion of the current lack of accredited EQAS for many new and some established hematology parameters.
  • Consideration of internal quality control limitations for certain parameters and instruments.

    • Main Results:

    • Several new CBC parameters, including leukocyte positional parameters, are available but not yet widely used clinically due to lack of EQAS.
    • Established parameters like mean platelet volume and red cell distribution width also lack available EQAS.
    • A workshop was held to discuss the need for EQAS for these parameters and to seek consensus on priorities.

    Conclusions:

    • The clinical utility of new CBC parameters is hindered by the absence of accredited external quality assessment schemes.
    • The lack of EQAS and, in some cases, internal quality control raises concerns about using these parameters for clinical decision-making.
    • Prioritizing parameters for future EQAS is essential to ensure the reliability and adoption of advanced hematology diagnostics.