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Use of an Influenza Antigen Microarray to Measure the Breadth of Serum Antibodies Across Virus Subtypes
Published on: July 26, 2019
Improving seasonal and pandemic influenza vaccines
Melanie Saville1, Grenville Marsh, Agnes Hoffenbach
1Research and Development Department, Sanofi Pasteur, 1541 Av. Marcel Mérieux, 69280 Marcy L Etoile, France. melanie.saville@sanofipasteur
Abstract:
Challenges facing seasonal and pandemic influenza vaccination include: increasing the immunogenicity of seasonal vaccines for the most vulnerable, increasing vaccination coverage against seasonal influenza, and developing vaccines against pandemic strains that are immunogenic with very low quantities of antigen to maximize the number of people who can be vaccinated with a finite production capacity. We review Sanofi Pasteur's epidemic and pandemic influenza research and development programmes with emphasis on two key projects: intradermal influenza vaccine for seasonal vaccination of both elderly and younger adults, and pandemic influenza vaccine.
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