Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Immunologic studies in myelodysplastic syndrome].

L Molnár1, T Burger, M Schmelczer

  • 1Pécsi Orvostudományi Egyetem II. sz. Belgyógyászati Klinika.

Orvosi Hetilap
|October 20, 1991
PubMed
Summary

Myelodysplastic syndrome (MDS) patients often show reduced T-cells and NK-cells, alongside increased immunoglobulins. These lymphoid abnormalities are more pronounced in patients with excess blasts, suggesting a broader impact of MDS.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of VEGF in the differential growth between the fetal and placental ends of the umbilical cord.

Journal of neonatal-perinatal medicine·2018
Same author

Assessment of a new method for the analysis of decomposition gases of polymers by a combining thermogravimetric solid-phase extraction and thermal desorption gas chromatography mass spectrometry.

Journal of chromatography. A·2014
Same author

[The uterovesical fistula - report of a rare cause of incontinence and review of the literature].

Aktuelle Urologie·2014
Same author

[Tethered tape or the fourth factor. A new cause of recurrent stress incontinence after midurethral tape procedures vaginal tape insertion].

Der Urologe. Ausg. A·2013
Same author

Hydrated lime for metals immobilization and explosives transformation: Treatability study.

Journal of hazardous materials·2012
Same author

Removal of nonspecific binding proteins from cell and tissue extracts using 2-aminobenzimidazole-tethered affinity resin.

Die Pharmazie·2011

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Context:

  • Myelodysplastic syndrome (MDS) is primarily a myeloid stem cell disorder.
  • Emerging evidence suggests potential involvement of the lymphoid system in MDS.
  • Understanding lymphoid abnormalities in MDS is crucial for comprehensive patient care.

Purpose:

  • To investigate lymphoid system abnormalities in patients with myelodysplastic syndrome.
  • To assess lymphocyte counts, subpopulations, and immunoglobulin levels in MDS patients.
  • To correlate lymphoid findings with the presence of excess blasts in MDS.

Summary:

  • This study examined 25 myelodysplastic syndrome (MDS) patients, evaluating lymphocyte counts, subpopulations (T-cells, B-cells, NK-cells), and immunoglobulin levels.
  • Results revealed lymphopenia, reduced T-cell (especially T4-cells) and NK-cell (Leu7+) counts, and frequent polyclonal hypergammaglobulinaemia.

Related Experiment Videos

  • These lymphoid abnormalities were more severe in MDS patients with excess blasts.

    • Impact:

    • Findings indicate that MDS affects not only myeloid but also lymphoid cell lines.
    • The study highlights the potential for immune dysregulation in MDS.
    • Identifying lymphoid involvement may refine prognostic assessments and therapeutic strategies for MDS.