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Related Experiment Videos

Neuronal changes in psoriasis exacerbation.

H El-Nour1, A Santos, M Nordin

  • 1Department of Medicine, Solna, Karolinska University Hospital, Stockholm, Sweden. husameldin.elnour@ki.se

Journal of the European Academy of Dermatology and Venereology : JEADV
|May 21, 2009
PubMed
Summary

This study reveals altered nerve fiber expression and substance P signaling in psoriasis during flare-ups. These changes indicate a significant nervous system involvement in psoriasis exacerbation.

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Area of Science:

  • Dermatology
  • Neuroscience
  • Immunology

Background:

  • The nervous system plays a role in inflammatory skin conditions.
  • Psoriasis is a chronic inflammatory skin disease with potential neurological links.

Purpose of the Study:

  • To investigate the specific contribution of nerve fibers to psoriasis during both remission and exacerbation phases.
  • To analyze neuronal markers and their receptors in psoriatic skin.

Main Methods:

  • Immunohistochemistry was used to examine neuronal markers: protein gene product 9.5 (PGP 9.5), growth-associated protein-43 (GAP-43), and substance P.
  • The study also assessed the expression of substance P's receptor, neurokinin-1R (NK-1R).
  • Samples were analyzed from seven female patients with psoriasis during remission and exacerbation, as well as from non-involved skin.

Main Results:

  • Decreased epidermal PGP 9.5 nerve fibers were observed in involved skin during exacerbation compared to remission and non-involved skin.
  • GAP-43 positive nerve fibers and substance P positive nerve fibers were also reduced in involved skin during exacerbation.
  • An increase in neurokinin-1R (NK-1R) expressing cells was noted in involved psoriatic skin during exacerbation.

Conclusions:

  • The findings suggest a significant interaction between the nervous system and inflammation in psoriasis.
  • Altered expression of nerve fibers, substance P, and NK-1R points to a role for neuro-immune crosstalk in psoriasis exacerbation.