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Related Experiment Video

Updated: Jun 23, 2026

Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis

Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis

Published on: December 8, 2011

Candidiasis (vulvovaginal).

¹General Practice, Glasgow University, Glasgow, Scotland.

BMJ Clinical Evidence

|May 21, 2009

Summary

This summary is machine-generated.

This systematic review evaluates treatments for vulvovaginal candidiasis, commonly known as a yeast infection. It found various drug and alternative therapies effective for acute and recurrent cases in non-pregnant women.

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Area of Science:

Gynecology
Infectious Diseases
Evidence-Based Medicine

Background:

Vulvovaginal candidiasis (VVC) is a common gynecological condition, second only to bacterial vaginosis.
Candida albicans is the primary causative agent, responsible for 85-90% of VVC cases.

Purpose of the Study:

To systematically review the effectiveness and safety of various treatments for acute and recurrent vulvovaginal candidiasis in non-pregnant women.
To assess the impact of treating male sexual partners on symptom resolution and recurrence prevention.
To evaluate treatments for asymptomatic women with a positive Candida swab.

Main Methods:

A systematic review of literature was conducted, searching databases including Medline, Embase, and The Cochrane Library up to October 2006.
Included were systematic reviews, randomized controlled trials (RCTs), and observational studies.
Harms alerts from regulatory agencies like the FDA and MHRA were also incorporated.

Main Results:

The review identified 58 studies meeting the inclusion criteria.
A GRADE evaluation was performed to assess the quality of evidence for different interventions.
Information on the effectiveness and safety of numerous treatments was compiled.

Conclusions:

The review presents data on the effectiveness and safety of diverse interventions for VVC.
Interventions evaluated include drug treatments, alternative therapies, and partner treatment.
Specific treatments discussed encompass oral fluconazole, oral itraconazole, intravaginal preparations (e.g., boric acid, nystatin, imidazoles, tea tree oil), and probiotics like Lactobacillus acidophilus.