Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
Borderline Personality Disorder01:25

Borderline Personality Disorder

Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
Genetic and Environmental Contributions
Borderline Personality...
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Panic Disorder01:27

Panic Disorder

Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...
Personality Disorders: Schizotypal and Histrionic01:20

Personality Disorders: Schizotypal and Histrionic

Schizotypal personality disorder and histrionic personality disorder are two distinct psychological conditions classified under personality disorders, each characterized by unique behavioral patterns and social difficulties. Both disorders significantly affect interpersonal relationships and emotional well-being, leading to social isolation and frustration.
Schizotypal Personality Disorder: Eccentric Behavior and Social Withdrawal
Schizotypal personality disorder is marked by odd or eccentric...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ongoing Changes in Web Searches for Health-Related Information.

Pharmacopsychiatry·2026
Same author

Investigating prognostic classifications of preexisting multiple long-term conditions for health outcomes 1 year after COVID-19 hospitalization: A UK prospective observational study.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2026
Same author

Increasing use of generative artificial intelligence by teenagers.

The British journal of psychiatry : the journal of mental science·2026
Same author

Cost-effectiveness of pramipexole augmentation for acute phase and maintenance therapy of treatment-resistant depression compared to placebo augmentation: economic evaluation of the PAX-D randomised controlled trial.

The Lancet regional health. Europe·2025
Same author

Anthropomorphic technology in everyday life: focus on chatbots and impacts on mental health.

European archives of psychiatry and clinical neuroscience·2025
Same author

Pramipexole augmentation for the acute phase of treatment-resistant, unipolar depression: a placebo-controlled, double-blind, randomised trial in the UK.

The lancet. Psychiatry·2025

Related Experiment Video

Updated: Jun 23, 2026

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Bipolar disorder.

John R Geddes1, David Briess

  • 1Department of Psychiatry, University of Oxford, Oxford, UK.

BMJ Clinical Evidence
|May 21, 2009
PubMed
Summary
This summary is machine-generated.

This systematic review examines treatments for bipolar disorder, covering mania, depression, and relapse prevention. It synthesizes evidence from 60 studies on various pharmacological and psychological interventions for improved patient outcomes.

Related Experiment Videos

Last Updated: Jun 23, 2026

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Pharmacology

Background:

  • Bipolar disorder affects up to 1.5% of adults, characterized by mood swings between depression and mania.
  • It significantly increases risks of suicide and disability, with many experiencing residual dysfunction or recurrent episodes.

Purpose of the Study:

  • To systematically review the effects of treatments for mania in bipolar disorder.
  • To evaluate treatments for bipolar depression.
  • To assess interventions for preventing relapse of mania or bipolar depression.

Main Methods:

  • Conducted a systematic review of medical literature up to July 2006.
  • Included data from 60 systematic reviews, randomized controlled trials (RCTs), and observational studies.
  • Incorporated harms alerts from regulatory agencies like the FDA and MHRA.

Main Results:

  • Identified numerous interventions for bipolar disorder treatment.
  • Evaluated the quality of evidence for various interventions using the GRADE system.
  • Included a wide range of pharmacological agents and psychological therapies.

Conclusions:

  • Presents information on the effectiveness and safety of multiple bipolar disorder interventions.
  • Lists key treatments evaluated, including antidepressants, mood stabilizers (e.g., lithium, valproate), antipsychotics (e.g., olanzapine, quetiapine), and psychological therapies.
  • Provides a comprehensive overview of evidence for managing bipolar disorder symptoms and preventing relapse.