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Using Chicken Embryo as a Powerful Tool in Assessment of Developmental Cardiotoxicities
Published on: March 21, 2021
Bendiocarbamate toxicity in the chick embryo
E Peterovová1, D Sedmera, I Mísek
1Department of Biology and Genetics, University of Veterinary Medicine in Kosice, Kosice, Slovak Republic.
Folia Biologica
|May 21, 2009
Summary
Bendiocarbamate, a carbamate pesticide, showed low toxicity in chick embryos. Developmental exposure did not result in significant malformations or toxicity, indicating safety for avian development.
Area of Science:
- Toxicology
- Developmental Biology
- Environmental Science
Background:
- Carbamate pesticides are generally considered low toxicity to vertebrates.
- Limited developmental toxicity data exists for carbamate pesticides.
- Avian embryos are a sensitive model for assessing developmental toxicity.
Purpose of the Study:
- To evaluate the embryotoxicity of the carbamate pesticide bendiocarbamate.
- To assess the impact of bendiocarbamate exposure on chick embryo development.
- To determine the safety profile of bendiocarbamate during avian embryonic development.
Main Methods:
- Chick embryos were exposed to bendiocarbamate via intra-embryonic administration on specific developmental days.
- Toxicity was assessed by determining LD50 values at different embryonic stages.
- Malformations, body weight, and apoptosis were evaluated in surviving embryos.
Main Results:
- Bendiocarbamate exhibited low toxicity, with LD50 values increasing with developmental stage.
- Malformations were rare (<3%) and observed in both control and experimental groups.
- A mild, dose-dependent reduction in body weight was noted, but apoptosis showed no significant increase.
Conclusions:
- Bendiocarbamate demonstrates low toxicity in avian embryos.
- Developmental exposure to bendiocarbamate does not lead to significant embryotoxic effects.
- Findings align with previous studies in other vertebrates, supporting the safety of bendiocarbamate in avian development.
