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Related Concept Videos

Bonding in Metals02:32

Bonding in Metals

Metallic bonds are formed between two metal atoms. A simplified model to describe metallic bonding has been developed by Paul Drüde called the “Electron Sea Model”.
Metallic Solids02:37

Metallic Solids

Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
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Metal-Ligand Bonds02:51

Metal-Ligand Bonds

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Masking and Demasking Agents

EDTA titrations may necessitate masking and demasking agents to temporarily protect a particular metal ion in a mixture from the EDTA reaction. These agents facilitate the sequential analysis of the metal ions by forming stable complexes with some—but not all—metal ions during certain steps.
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Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is formed in...
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Detection and Recovery of Palladium, Gold and Cobalt Metals from the Urban Mine Using Novel Sensors/Adsorbents Designated with Nanoscale Wagon-wheel-shaped Pores
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Detection and Recovery of Palladium, Gold and Cobalt Metals from the Urban Mine Using Novel Sensors/Adsorbents Designated with Nanoscale Wagon-wheel-shaped Pores

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A precious metal heist.

Eric P Skaar

    Cell Host & Microbe
    |May 21, 2009
    PubMed
    Summary
    This summary is machine-generated.

    Bacterial pathogens need iron to infect hosts. Salmonella Typhimurium overcomes the host

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    Area of Science:

    • Microbiology
    • Immunology
    • Pathogen-host interactions

    Background:

    • Iron is essential for bacterial pathogen survival and infection of vertebrate hosts.
    • Host lipocalin-2 sequesters bacterial siderophores, acting as an immune defense mechanism.
    • Bacterial siderophores are crucial for iron acquisition during infection.

    Discussion:

    • Salmonella Typhimurium evades lipocalin-2 mediated immunity.
    • This evasion is achieved through the production of a modified siderophore, salmochelin.
    • Understanding these evasion mechanisms is key to developing new anti-infective strategies.

    Key Insights:

    • Salmonella Typhimurium utilizes salmochelin to circumvent host iron sequestration by lipocalin-2.
    • This highlights a specific molecular strategy employed by pathogens to overcome host defenses.
    • The study demonstrates a direct conflict between host immunity and bacterial iron acquisition.

    Outlook:

    • Further research into pathogen siderophore modifications can reveal novel therapeutic targets.
    • Investigating the structural basis of salmochelin's interaction with lipocalin-2 may inform drug design.
    • This work contributes to the broader understanding of bacterial pathogenesis and host immune evasion.