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Related Experiment Videos

Association between statin therapy and tendon rupture: a case-control study.

Abhimanyu Beri¹, Francesca C Dwamena, Ben A Dwamena

¹Department of Internal Medicine, Michigan State University, East Lansing, MI, USA. abhiberi@gmail.com

Journal of Cardiovascular Pharmacology

|May 21, 2009

Summary

This study found no overall link between statin use and tendon rupture. However, women experiencing tendon rupture were more likely to have been using statins, suggesting a potential sex-specific risk.

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Area of Science:

Pharmacovigilance
Orthopedic Surgery
Epidemiology

Background:

Case reports suggest a possible link between statin therapy and tendon rupture.
Analytical studies investigating this association have been lacking.

Purpose of the Study:

To assess if statin use is a risk factor for tendon rupture.
To investigate the relationship using a case-control study design.

Main Methods:

A case-control study was conducted using electronic medical records from 2002-2007.
93 cases of tendon rupture were compared with 279 matched controls for statin exposure within the preceding 12 months.
Multivariate logistic regression controlled for diabetes, renal disease, rheumatologic disease, and steroid use.

Main Results:

No significant overall difference in statin use was found between tendon rupture cases and controls (OR = 1.10, 95% CI 0.57-2.13).
Subgroup analysis revealed statin use as a significant risk factor for tendon rupture in women (aOR = 3.76, 95% CI 1.11-12.75).
No significant association was observed in men (aOR = 0.66, 95% CI 0.29-1.51).

Conclusions:

Overall, statin therapy is not associated with an increased risk of tendon rupture.
A potential sex-specific association exists, with women showing a higher likelihood of statin use preceding tendon rupture.