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Related Experiment Video

Updated: Jun 23, 2026

Generation of Induced Pluripotent Stem Cells from Turner Syndrome (45XO) Fetal Cells for Downstream Modelling of Neurological Deficits Associated with the Syndrome

Generation of Induced Pluripotent Stem Cells from Turner Syndrome (45XO) Fetal Cells for Downstream Modelling of Neurological Deficits Associated with the Syndrome

Published on: December 4, 2021

Multiple pilomatrixoma in Turner syndrome.

Alan R Bengtzen¹, Hans E Grossniklaus, C Robert Bernardino

¹Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.

Ophthalmic Plastic and Reconstructive Surgery

|May 21, 2009

Summary

Multiple pilomatrixoma, typically rare, appeared in a patient with Turner syndrome. This case highlights the importance of considering Turner syndrome in individuals with numerous pilomatrixoma lesions.

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Area of Science:

Dermatology
Genetics
Pediatrics

Background:

Pilomatrixoma is a common, benign skin tumor originating from the hair follicle matrix.
It typically presents as a solitary lesion with a low rate of recurrence.

Observation:

A case study involving a 13-year-old female patient with Turner syndrome.
The patient presented with ten distinct facial pilomatrixoma lesions over a seven-year period.
Histopathological examination confirmed all lesions as pilomatrixoma.

Findings:

The occurrence of multiple pilomatrixoma in this patient is highly unusual.
The association suggests a potential link between multiple pilomatrixoma and Turner syndrome.

Implications:

The presence of multiple pilomatrixoma should prompt consideration for underlying genetic conditions like Turner syndrome.
This finding may aid in earlier diagnosis and management of Turner syndrome in pediatric patients.
Further research is warranted to explore the genetic and molecular mechanisms connecting pilomatrixoma and Turner syndrome.