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Related Experiment Video

Updated: Jun 23, 2026

Social Defeat Stress Model for Adolescent C57BL&#47;6 Male and Female Mice
07:15

Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice

Published on: March 15, 2024

Stress signalling pathways that impair prefrontal cortex structure and function.

Amy F T Arnsten1

  • 1Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA. amy.arnsten@yale.edu

Nature Reviews. Neuroscience
|May 21, 2009
PubMed
Summary
This summary is machine-generated.

Stress significantly impairs prefrontal cortex (PFC) cognitive functions by altering intracellular pathways. Understanding these stress signaling pathways is crucial for addressing PFC dysfunction in mental illness.

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Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
08:42

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Stress Research

Background:

  • The prefrontal cortex (PFC) is critical for higher-order cognition.
  • The PFC is highly vulnerable to stress, which impairs cognitive abilities.
  • Stress can cause structural changes in the PFC.

Purpose of the Study:

  • To investigate the intracellular signaling pathways mediating stress effects on the PFC.
  • To understand the link between stress signaling and PFC dysfunction in mental illness.

Main Methods:

  • Review of recent research on stress signaling in the PFC.
  • Analysis of intracellular mechanisms affected by stress exposure.

Main Results:

  • Stress rapidly diminishes PFC cognitive functions.
  • Prolonged stress leads to architectural changes in PFC dendrites.
  • Intracellular signaling pathways are key mediators of stress effects on the PFC.

Conclusions:

  • Disinhibition of stress signaling pathways contributes to PFC dysfunction.
  • This research offers insights into the neurobiological basis of mental illness involving PFC deficits.