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Single-Molecule Measurement of Protein Interaction Dynamics Within Biomolecular Condensates
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Functionality and the evolution of marginal stability in proteins: inferences from lattice simulations

Paul D Williams1, David D Pollock, Richard A Goldstein

  • 1Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

Evolutionary Bioinformatics Online
|May 21, 2009
PubMed
Summary

Marginal protein stability, often linked to function, can arise from neutral evolution. Our simulations show that even without selection for function, protein evolution naturally leads to marginal stability.

Keywords:
lattice modelsmolecular evolutionprotein thermodynamics

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