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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

Ribosome Profiling

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...

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Related Experiment Video

Updated: Jun 23, 2026

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

Published on: January 25, 2011

Analysis of gene expression data using BRB-ArrayTools.

Richard Simon¹, Amy Lam, Ming-Chung Li

¹Biometric Research Branch, National Cancer Institute, Bethesda, MD 20892-7434, USA. rsimon@nih.gov

Cancer Informatics

|May 21, 2009

Summary

This summary is machine-generated.

BRB-ArrayTools offers comprehensive DNA microarray analysis for biomedical scientists. This software provides advanced statistical methods and tools for gene expression data analysis and predictive classifier development.

Keywords:

Bioinformatics biostatistics gene expression microarrays

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Bacterial Gene Expression Analysis Using Microarrays

Bacterial Gene Expression Analysis Using Microarrays

Published on: May 28, 2007

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Last Updated: Jun 23, 2026

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

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Bacterial Gene Expression Analysis Using Microarrays

Bacterial Gene Expression Analysis Using Microarrays

Published on: May 28, 2007

Area of Science:

Bioinformatics
Biostatistics
Genomics

Background:

DNA microarrays generate large gene expression datasets.
Analyzing high-dimensional genomic data requires specialized statistical methods.
Biomedical scientists need accessible tools for advanced data analysis.

Purpose of the Study:

To introduce BRB-ArrayTools, an integrated software system for DNA microarray analysis.
To provide biomedical scientists with state-of-the-art statistical methods for gene expression data.
To facilitate the development of predictive classifiers and pathway analysis.

Main Methods:

BRB-ArrayTools integrates comprehensive statistical methods for DNA microarray analysis.
The software includes extensive tools for predictive classifier development and cross-validation.
It provides links to genomic websites for annotation and pathway analysis tools.

Main Results:

BRB-ArrayTools offers a wide array of tools for analyzing gene expression data.
The system supports the development and validation of predictive models.
It includes access to over 100 public microarray datasets and imports data from NCBI's Gene Expression Omnibus.

Conclusions:

BRB-ArrayTools is a powerful, user-friendly software for biomedical scientists.
It enhances the statistical analysis of DNA microarray data.
The system aids in gene annotation, pathway analysis, and predictive modeling.