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Related Experiment Video

Updated: Jun 23, 2026

Microdissection and Immunofluorescence Staining of Myocardial Sleeves in Murine Pulmonary Veins

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Published on: November 21, 2023

Myocardial cleft, crypt, diverticulum, or aneurysm? Does it really matter?

Luis Afonso¹, Anupama Kottam, Vipin Khetarpal

¹Division of Cardiology, Department of Internal Medicine, Wayne State University, Detroit, Michigan, USA. lafonso@med.wayne.edu

Clinical Cardiology

|May 21, 2009

Summary

Myocardial clefts are congenital heart abnormalities causing myocardial fiber disarray. This report clarifies their terminology and differential diagnosis, noting their presence in healthy individuals and hypertrophic cardiomyopathy.

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Area of Science:

Cardiology
Cardiac Imaging
Congenital Heart Abnormalities

Background:

Myocardial clefts are congenital abnormalities characterized by myocardial fiber or fascicle disarray.
These findings have been observed in both healthy volunteers and patients with hypertrophic cardiomyopathy.

Observation:

A myocardial cleft is a discrete, V-shaped fissure within the myocardium.
It tends to narrow or occlude during systole without causing local hypokinesia or dyskinesia.

Findings:

The clinical significance of myocardial clefts remains largely unknown.
This report addresses the confusing terminology and differential diagnosis associated with this condition.

Implications:

Clarifying the definition and diagnosis of myocardial clefts is crucial for accurate patient assessment.
Further research is needed to understand the clinical implications of myocardial clefts in various cardiac conditions.