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Measles revaccination response in a school-age population
R R Wittler1, B C Veit, S McIntyre
1Department of Pediatrics, William Beaumont Army Medical Center, El Paso, Texas 79920.
Pediatrics
|November 1, 1991
Summary
Measles revaccination is crucial, as 9.8% of previously vaccinated children remained susceptible. Booster shots are more effective when given at 11-12 years old compared to 4-6 years old.
Area of Science:
- Immunology
- Epidemiology
- Public Health
Background:
- Measles incidence surged, prompting revised immunization policies for a two-dose schedule.
- Assessing measles immunity in vaccinated populations is vital for public health strategies.
Purpose of the Study:
- Determine the prevalence of measles-susceptible individuals in vaccinated school-aged military dependents.
- Identify risk factors associated with measles immunological susceptibility.
Main Methods:
- Serum samples collected pre- and post-measles revaccination.
- Measles-specific IgG and IgM titers analyzed using enzyme-linked immunosorbent assay (ELISA).
- Statistical analysis included repeated-measures ANOVA and trend analysis.
Main Results:
- 9.8% of the studied population remained immunologically susceptible to measles.
- Time since last vaccination correlated with IgG titers.
- Age at initial vaccination influenced revaccination response and susceptibility.
Conclusions:
- Continued measles revaccination is supported by the findings.
- Revaccination at 11-12 years of age shows greater immunological benefit than at 4-6 years.