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Updated: Jun 23, 2026

Assessing Cytotoxicity of Metabolites of Typical Triazole Pesticides in Plants
Published on: December 22, 2023
Cytotoxic 3,4-seco-cycloartane triterpenes from Gardenia sootepensis
Thanesuan Nuanyai1, Reungrit Sappapan, Thapong Teerawatananond
1Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
Abstract:
Five new 3,4-seco-cycloartanes, sootepins A-E (1-5), along with four known triterpenes (6-9), were isolated from the apical buds of Gardenia sootepensis. Their structures were elucidated on the basis of spectroscopic methods (1D and 2D NMR, HRESIMS, and X-ray crystallography), and the compounds were tested for in vitro cytotoxic activity against human breast (BT474), lung (CHAGO), liver (Hep-G2), gastric (KATO-3), and colon (SW-620) cancer cell lines. Generally, the compounds possessing an exomethylene gamma-lactone ring showed broad cytotoxicity for all cell lines tested.
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