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Updated: Feb 14, 2026
Single-cell Gene Expression Profiling Using FACS and qPCR with Internal Standards
Published on: February 25, 2017
Stress repression in restrained rats by (R)-(-)-linalool inhalation and gene expression profiling of their whole
Akio Nakamura1, Satoshi Fujiwara, Ichiro Matsumoto
1Technical Research Center, T Hasegawa Co, Ltd, Kawasaki-shi, Japan. akio_nakamura@t-hasegawa.co.jp
Abstract:
As an attempt to quantitatively analyze the physiopsychological effects elicited by odorants, white blood cells and gene expression were profiled in the whole blood of the rats exposed to (R)-(-)-linalool during restraint stress for 2 h. In neutrophils and lymphocytes, significant changes caused by the restraint were repressed by their exposure to the odorant. This indicates that inhalation attenuates stress-induced changes. Significant changes on the stress-induced variations were induced by inhalation in 115 gene expression levels. Of those, 109 genes were down-regulated, whereas the remaining 6 were up-regulated. These findings show that (R)-(-)-linalool inhalation represses stress-induced effects on the profiles of both blood cells and gene expression. Furthermore, these results suggest the possibility that the odorant-induced effects can be quantitatively evaluated by analyzing the profiles of blood cells and gene expression.
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