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An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
Published on: November 28, 2010
Cellular immunotherapy for ovarian cancer.
Martin J Cannon1, Timothy J O'Brien
1University of Arkansas for Medical Sciences, Department of Microbiology and Immunology, 4301 West Markham, Little Rock, AR 72205, USA. mjcannon@uams.edu
Expert Opinion on Biological Therapy
|May 22, 2009
Summary
Cellular immunotherapy shows promise for treating ovarian cancer, particularly dendritic cell vaccination and adoptive T-cell immunotherapy. Innovations focus on overcoming tumor-associated immune suppression to prevent disease recurrence.
Area of Science:
- Immunology
- Oncology
- Cellular Therapy
Background:
- Ovarian cancer often presents at advanced stages with high recurrence and mortality rates despite initial treatment.
- Cellular immunotherapy offers a potential strategy to prevent or delay recurrent metastatic ovarian cancer.
Purpose of the Study:
- To review current innovations in cellular immunotherapy for ovarian cancer.
- To focus on dendritic cell vaccination and adoptive T-cell immunotherapy.
Main Methods:
- Appraisal of the current state of cellular immunotherapy for ovarian cancer.
- Discussion of ovarian cancer's immune evasion mechanisms, including regulatory T cells.
- Exploration of novel techniques to enhance cellular immunotherapy efficacy against immune suppression.
Main Results:
- Ovarian cancer exemplifies tumor-associated immune suppression.
- Regulatory T cells play a significant role in preventing immune attack.
Conclusions:
- Targeting tumor-associated regulatory T cells is crucial for effective ovarian cancer immunotherapy.
- Innovative strategies to antagonize regulatory T cells may lead to future treatment advancements.
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