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In Vitro and In Vivo Models to Study Corneal Endothelial-mesenchymal Transition
Published on: August 20, 2016
Selective MMP-12 inhibitors: WO-2008057254
1Norman Consulting, 18 Pink Lane, Burnham, Buckinghamshire, UK. peter.norman2@btinternet.com
Expert Opinion on Therapeutic Patents
|May 22, 2009
Abstract:
Amino-substituted xanthene, thioxanthene and carbazole sulfonamido-carboxylic acid of carboxamido carboxylic acid derivatives, their use to treat metalloprotease mediated conditions, and especially to inhibit MMP-12, and to treat osteoarthritis, rheumatoid arthritis, atherosclerosis, heart failure, fibrosis, pulmonary emphysema, tumour growth, asthma and chronic obstructive pulmonary disorder (COPD). Compounds of this category are suggested to be particularly useful in the treatment of COPD.