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Long-patch Base Excision Repair01:02

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The Use of the Ex Vivo Chandler Loop Apparatus to Assess the Biocompatibility of Modified Polymeric Blood Conduits
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Routine patch testing with the preservative system Kathon CG.

A C Groot1, D P Bruynzeel, J G Schroeff

  • 1Departments of Dermatology, Carolus & Willem-Alexander Hospital, PO Box 90152, 5200 MD 's-Hertogenbosch, Amsterdam.

International Journal of Cosmetic Science
|May 22, 2009
PubMed
Summary
This summary is machine-generated.

Kathon CG, a common preservative, caused allergic contact dermatitis in 5.0% of patients patch tested. Moisturizing creams were the most frequent cause of these reactions, particularly in women with hand or facial dermatitis.

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Area of Science:

  • Dermatology
  • Allergology
  • Cosmetic Science

Background:

  • Allergic contact dermatitis (ACD) is a significant health concern.
  • Kathon CG (a mixture of methylchloroisothiazolinone and methylisothiazolinone) is a widely used preservative in consumer products.
  • Patch testing is a standard diagnostic tool for ACD.

Purpose of the Study:

  • To evaluate the prevalence and relevance of positive patch test reactions to Kathon CG in patients with suspected allergic contact dermatitis.
  • To identify common sources of sensitization and clinical presentations associated with Kathon CG allergy.

Main Methods:

  • A retrospective analysis of 1620 patients patch tested with Kathon CG (100 p.p.m. aqua).
  • Data collection included patient demographics, clinical presentation, dermatitis location, and suspected exposure sources.
  • Assessment of reaction relevance to the presenting dermatitis.

Main Results:

  • A total of 81 patients (5.0%) showed a positive patch test reaction to Kathon CG.
  • Sixty-two reactions (3.8%) were deemed relevant to the patients' clinical condition.
  • The majority of affected patients were female, presenting with hand and/or facial dermatitis.
  • Cosmetic products were the sensitizing agent in 46% of cases on healthy skin.
  • Pre-existing dermatitis, including atopic and irritant dermatitis, was present in 54% of sensitized individuals.
  • Moisturizing creams were identified as the most common cause of relevant reactions.

Conclusions:

  • Kathon CG is a relevant contact allergen, contributing to allergic contact dermatitis in a notable percentage of patients.
  • Awareness of Kathon CG as a potential allergen is crucial for dermatologists and patients, especially those with hand/facial dermatitis or pre-existing skin conditions.
  • Further investigation into product formulations and consumer education may help reduce sensitization rates.