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Updated: Jun 23, 2026

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates
Published on: February 23, 2018
Comparison of diffusion by anionic surfactants through cellulose acetate and collagen membranes
M T García Ramón1, I Ribosa, J S Leal
1Asociación Investigación Detergentes (AID), Instituto de Tecnologia Química y Textil (CSIC), C/ Girona Salgado 18-26, 08034 Barcelona, Spain.
Abstract:
Synopsis From a dermatological point of view, it is important to know what is the irritation potential of surfactants on human skin. Recent research trends have been oriented towards the establishment of new 'in vitro' techniques that will avoid animal experimentation. In this paper, some results on the rate of diffusion of different anionic surfactants through both cellulose acetate and collagen membranes are described. A correlation between results of diffusion through the protein membrane and results published on the same surfactants and their irritation potential during 'in vivo' experiments appears possible.
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