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Minimal Erythema Dose (MED) Testing
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Comparison between evaluation methods from sun protection factors.

M C Martini1

  • 1Faculté de Pharmacie de Lyon, Laboratoire de Pharmacie Industrielle et Technologie Parapharmaceutique, 8 avenue Rockefeller, 69008 Lyon, France.

International Journal of Cosmetic Science
|May 22, 2009
PubMed
Summary
This summary is machine-generated.

Evaluating Sun Protection Factors (SPF) requires objective methods. An in vitro method using an integration sphere correlates well with in vivo SPF, while a new combined human testing method offers reliable results.

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Area of Science:

  • Dermatology
  • Photobiology
  • Cosmetic Science

Background:

  • Numerous objective methods exist for evaluating Sun Protection Factors (SPF).
  • In vitro and in vivo methods have varying degrees of correlation with human skin responses.
  • Standardized testing is crucial for accurate SPF determination.

Purpose of the Study:

  • To describe and compare common in vitro and in vivo methods for SPF evaluation.
  • To identify in vitro methods that correlate well with in vivo SPF.
  • To propose a new, combined human testing method for SPF determination.

Main Methods:

  • Comparison of spectrophotometric methods (solution, thin layer, integration sphere).
  • Evaluation of in vivo methods using albino guinea pigs and human subjects.
  • Description of the American (FDA) and German (DIN 67501) official SPF testing methods.
  • Introduction of a novel combined human testing protocol using a Xenon lamp and standardized product application.

Main Results:

  • In vitro methods involving an integration sphere show good correlation with in vivo SPF.
  • Albino guinea pig tests are useful for initial product screening but not definitive SPF values.
  • The proposed combined human testing method utilizes controlled irradiation and visual erythema assessment.

Conclusions:

  • An in vitro method with an integration sphere offers a reliable alternative for SPF assessment.
  • Human testing remains essential for determining true SPF values.
  • The newly proposed combined method aims to provide accurate and reliable SPF determination.