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Measuring and Modeling Contractile Drying in Human Stratum Corneum
Published on: March 1, 2017
Hydration of the stratum corneum
1Beecham Products Research Department, St George's Avenue, Weybridge, Surrey KT13 0DE, UK.
International Journal of Cosmetic Science
|May 22, 2009
Summary
Topical glycerol and occlusion effectively hydrate the stratum corneum, reducing skin roughness and improving appearance. Glycerol
Area of Science:
- Dermatology and cosmetic science
- Skin physiology
- Materials science
Background:
- The stratum corneum's hydration significantly impacts skin barrier function and molecule penetration.
- Understanding skin hydration mechanisms is crucial for developing effective skincare and cosmetic products.
Purpose of the Study:
- To investigate and characterize changes in the hydrated stratum corneum using topical water, occlusion, and glycerol.
- To evaluate the effects of these treatments on skin surface topography and water flux.
Main Methods:
- Non-invasive techniques including Servomed Evaporimeter for water flux measurement.
- Skin surface topography analysis using a novel profilometer, scanning electron microscopy, and macrophotography.
- In vivo glycerol penetration assessment via chemical analysis of sequentially stripped stratum corneum layers.
Main Results:
- Topical water provided only transient hydration due to rapid evaporation.
- Occlusion with polyethylene film resulted in prolonged hydration, reduced roughness, and smoother skin.
- Glycerol reduced natural water flux and evaporation, leading to smoother skin with effects lasting over 24 hours.
- Glycerol's persistence was attributed to its diffusion into the stratum corneum, forming a reservoir.
Conclusions:
- Humectants like glycerol can achieve significant skin hydration and improve skin appearance.
- Glycerol offers a cosmetically acceptable method for skin hydration, impacting barrier function and penetration.
- The study suggests humectants are a viable alternative to occlusive agents for achieving beneficial skin hydration.
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