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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Mutations01:35

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Related Experiment Video

Updated: Jun 23, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

[Radiotherapy in dermatology].

A Marín1, E Vargas-Díez, L Cerezo

  • 1Servicio de Oncología. Hospital Universitario de La Princesa. Madrid. España. amarin.hlpr@salud.madrid.org

Actas Dermo-Sifiliograficas
|May 22, 2009
PubMed
Summary
This summary is machine-generated.

Radiotherapy uses ionizing radiation to damage cancer cell DNA, proving most effective for fast-growing tumors. Fractionated radiotherapy, with smaller doses over time, enhances treatment effectiveness and reduces side effects for skin cancer patients.

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Stereotactic Radiosurgery for Gynecologic Cancer
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Stereotactic Radiosurgery for Gynecologic Cancer

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Last Updated: Jun 23, 2026

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Dermatologic Surgery

Context:

  • Ionizing radiation induces cell death via DNA damage, disproportionately affecting undifferentiated tumor cells with high mitotic rates.
  • Fractionated radiotherapy regimens enhance treatment efficacy and patient tolerance.
  • Increased fractionation, utilizing lower doses per session, is key to minimizing adverse effects.

Purpose:

  • To review the principles and applications of radiotherapy in skin cancer treatment.
  • To highlight the importance of fractionated regimens and delayed assessment of treatment response.
  • To discuss modern radiotherapy techniques and their outcomes in skin cancer management.

Summary:

  • Radiotherapy is a crucial treatment for selected skin cancers, with modern techniques yielding high tumor control rates.
  • Fractionation strategies, including dose per session and overall treatment duration, are critical for optimizing outcomes and minimizing toxicity.
  • Final treatment response assessment should be deferred for at least three months post-radiotherapy due to the delayed effects of radiation on tumor cells.

Impact:

  • Modern radiotherapy equipment and techniques provide excellent tumor control with favorable cosmetic results and preserved function.
  • The selection of radiotherapy technique is tailored to individual tumor characteristics, including size, site, and thickness.
  • Widely adopted techniques include external beam radiotherapy using linear accelerators and high-dose-rate brachytherapy.