Related Experiment Video
Updated: Jun 23, 2026
08:25
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
[Contact sensitization to Euxyl K-400]
M T Bordel-Gómez1, A Miranda-Romero
1Servicio de Dermatología. Complejo Asistencial Virgen de la Concha. Zamora. España. matebordel@yahoo.es
Actas Dermo-Sifiliograficas
|May 22, 2009
Summary
Euxyl K400 sensitization affects 1.4% of patients, with methyldibromoglutaronitrile (MDGN) being the primary sensitizer. Sensitization to Euxyl K400 showed good agreement with MDGN but poor agreement with 2-phenoxyethanol.
Area of Science:
- Dermatology
- Allergology
- Cosmetic Science
Context:
- Euxyl K400, a preservative in cosmetics and topical drugs, contains methyldibromoglutaronitrile (MDGN) and 2-phenoxyethanol.
- Preservative sensitization is a growing concern in dermatology and allergy units.
Purpose:
- To determine the prevalence of Euxyl K400 sensitization.
- To assess sensitization to its individual components, MDGN and 2-phenoxyethanol.
- To evaluate the agreement between sensitization to Euxyl K400 and its components.
Summary:
- A retrospective study analyzed 1,092 patients over 5 years, using standard allergy testing including 0.3% MDGN and 1% 2-phenoxyethanol.
- 1.4% of patients showed Euxyl K400 sensitization, with 11 positive to MDGN and 2 to 2-phenoxyethanol.
- Sensitization was more common in men, with good agreement between Euxyl K400 and MDGN (Kp=0.68), but poor agreement with 2-phenoxyethanol (Kp=0.23).
Impact:
- Identifies MDGN as the main driver of Euxyl K400 sensitization.
- Provides data on preservative allergy prevalence for clinical practice.
- Informs cosmetic and pharmaceutical formulation regarding preservative safety.
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